Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer.

Das, Laxmidhar

Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer. [electronic resource] - PloS one 2015 - e0124000 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0124000 doi


Animals
Anticarcinogenic Agents--pharmacology
Antioxidants--metabolism
Consensus Sequence
Curcumin--pharmacology
Cyclooxygenase 2--genetics
Glutathione Reductase--genetics
Glutathione Transferase--genetics
Inflammation Mediators--metabolism
Liver--drug effects
Lymphoma, T-Cell--drug therapy
Male
Mice
Mice, Inbred AKR
NAD(P)H Dehydrogenase (Quinone)--genetics
NF-E2-Related Factor 2--genetics
Nitric Oxide Synthase Type II--genetics
Protein Binding--drug effects
RNA, Messenger--genetics
Signal Transduction--drug effects
Transforming Growth Factor beta1--genetics
Tumor Microenvironment--drug effects
Tumor Suppressor Protein p53--metabolism