An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

Sehgal, Alfica

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. [electronic resource] - Nature medicine May 2015 - 492-7 p. digital

Publication Type: Journal Article

1546-170X

10.1038/nm.3847 doi


Animals
Antithrombins--chemistry
Blood Coagulation--drug effects
Dose-Response Relationship, Drug
Factor IX--chemistry
Factor VIII--chemistry
Female
Hemophilia A--drug therapy
Hemostasis--drug effects
Homozygote
Humans
Male
Mice
Mutation
RNA Interference