The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.

Delire, Bénédicte

The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications. [electronic resource] - European journal of clinical investigation Jun 2015 - 609-23 p. digital

Publication Type: Journal Article; Review

1365-2362

10.1111/eci.12441 doi


Adaptor Proteins, Signal Transducing
Animals
Antineoplastic Agents--therapeutic use
Apoptosis Regulatory Proteins
Carcinogenesis--metabolism
Carcinoma, Hepatocellular--drug therapy
Humans
Intracellular Signaling Peptides and Proteins--physiology
Liver Neoplasms--drug therapy
MAP Kinase Signaling System--physiology
Membrane Proteins--physiology
Mice
Mitogen-Activated Protein Kinases--metabolism
Monomeric GTP-Binding Proteins--physiology
Mutation--genetics
Niacinamide--analogs & derivatives
Phenylurea Compounds--therapeutic use
Protein Kinase Inhibitors--therapeutic use
Rats
Sorafenib
Tumor Suppressor Proteins--physiology
raf Kinases--metabolism
ras GTPase-Activating Proteins--antagonists & inhibitors
ras Proteins--antagonists & inhibitors