Breaking the sensitivity limitations of cytochrome P450 oxidation product: dansyl chloride derivatisation of 4-OH mephenytoin, a CYP2C19 metabolite and its application to in vitro CYP inhibition assay.

Vijayabhaskar, V

Breaking the sensitivity limitations of cytochrome P450 oxidation product: dansyl chloride derivatisation of 4-OH mephenytoin, a CYP2C19 metabolite and its application to in vitro CYP inhibition assay. [electronic resource] - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May 2015 - 27-36 p. digital

Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

1873-376X

10.1016/j.jchromb.2015.02.031 doi


Cytochrome P-450 CYP2C19--chemistry
Dansyl Compounds--chemistry
Enzyme Assays--methods
Enzyme Inhibitors--chemistry
Kinetics
Mephenytoin--chemistry
Oxidation-Reduction