Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble.

Zhu, Shaolong

Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble. [electronic resource] - PloS one 2015 - e0120416 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0120416 doi


Deuterium Exchange Measurement
Glycogen Synthase Kinase 3--metabolism
Glycogen Synthase Kinase 3 beta
Intrinsically Disordered Proteins--metabolism
Kinetics
Mass Spectrometry--methods
Microscopy, Electron, Transmission
Models, Molecular
Phosphorylation
Protein Conformation
Tauopathies--pathology
tau Proteins--chemistry