Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery.

Gu, Jijin

Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. [electronic resource] - Biomaterials Mar 2015 - 99-114 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-5905

10.1016/j.biomaterials.2014.12.030 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics
Animals
Antibodies--metabolism
Cell Death--drug effects
DNA--metabolism
Doxorubicin--pharmacology
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Endocytosis--drug effects
Endosomes--drug effects
Female
Gene Silencing--drug effects
Gene Transfer Techniques
Genes, Reporter
Human Umbilical Vein Endothelial Cells
Humans
Hyaluronan Receptors--immunology
Intracellular Space--metabolism
MCF-7 Cells
Nanoparticles--chemistry
Plasmids--metabolism
Poloxalene--chemical synthesis
Polypropylenes--chemical synthesis
RNA, Messenger--genetics
RNA, Small Interfering--metabolism
Tissue Distribution--drug effects
Transfection