A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.

Payne, Claire Elizabeth

A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability. [electronic resource] - British journal of pharmacology May 2015 - 2654-70 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.13092 doi


Action Potentials--drug effects
Administration, Oral
Animals
Ganglia, Spinal--drug effects
HEK293 Cells
Humans
Membrane Potentials--drug effects
NAV1.8 Voltage-Gated Sodium Channel--drug effects
Nociception--drug effects
Pain Measurement--drug effects
Picolinic Acids--administration & dosage
Rats
Sensory Receptor Cells--drug effects
Sodium Channel Blockers--pharmacology
Tetrodotoxin--antagonists & inhibitors