Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells.

Morgan, R G

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells. [electronic resource] - British journal of cancer Feb 2015 - 714-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1532-1827

10.1038/bjc.2015.4 doi


Adenoma--genetics
Cell Membrane--metabolism
Colorectal Neoplasms--genetics
Food
Glucose--deficiency
Glycosylation
Humans
Neoplastic Stem Cells--metabolism
Protein Stability
Protein Transport
Receptors, G-Protein-Coupled--genetics
Stress, Physiological--physiology
Tumor Cells, Cultured
Tumor Microenvironment