The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans.
May, Patrick C
The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Jan 2015 - 1199-210 p. digital
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1529-2401
10.1523/JNEUROSCI.4129-14.2015 doi
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Peptides--blood
Animals
Aspartic Acid Endopeptidases--antagonists & inhibitors
Disease Models, Animal
Dogs
Heterocyclic Compounds, 2-Ring--pharmacokinetics
Humans
Mice
Picolinic Acids--pharmacokinetics
Protease Inhibitors--pharmacokinetics
The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Jan 2015 - 1199-210 p. digital
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1529-2401
10.1523/JNEUROSCI.4129-14.2015 doi
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Peptides--blood
Animals
Aspartic Acid Endopeptidases--antagonists & inhibitors
Disease Models, Animal
Dogs
Heterocyclic Compounds, 2-Ring--pharmacokinetics
Humans
Mice
Picolinic Acids--pharmacokinetics
Protease Inhibitors--pharmacokinetics