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Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation.

Huang, Ching-Ting

Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation. [electronic resource] - Cancer letters Apr 2015 - 117-26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 1872-7980

Standard No.: 10.1016/j.canlet.2015.01.007 doi

Subjects--Topical Terms:
Animals
Antineoplastic Agents--pharmacology
Ascites--metabolism
Cell Line, Tumor
Coculture Techniques
Dendritic Cells--drug effects
Female
Humans
Immunity, Cellular--drug effects
Insulin-Like Growth Factor I--genetics
Insulin-Like Growth Factor II--genetics
Interferon-gamma--metabolism
Interleukins--metabolism
Lymphocyte Activation
Mice, Inbred C57BL
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Neoplasm Staging
Ovarian Neoplasms--drug therapy
Phosphorylation
Pyrimidines--pharmacology
Pyrroles--pharmacology
Receptor, IGF Type 1--antagonists & inhibitors
Signal Transduction
T-Lymphocytes, Cytotoxic--immunology
Time Factors
Transfection
Tumor Necrosis Factor-alpha--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism