AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner.

Keenan, C M

AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. [electronic resource] - British journal of pharmacology May 2015 - 2406-18 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.13069 doi


Animals
Body Temperature Regulation--drug effects
CA1 Region, Hippocampal--drug effects
CA2 Region, Hippocampal--drug effects
CA3 Region, Hippocampal--drug effects
Cannabinoid Receptor Agonists--pharmacology
Cells, Cultured
Disease Models, Animal
Dose-Response Relationship, Drug
Dronabinol--analogs & derivatives
Enteric Nervous System--drug effects
Gastrointestinal Motility--drug effects
Hypothermia--drug therapy
Intestinal Mucosa--metabolism
Intestines--drug effects
Ligands
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Motor Activity--drug effects
Pain--drug therapy
Pain Threshold--drug effects
Receptor, Cannabinoid, CB1--agonists
Receptor, Cannabinoid, CB2--genetics
Stress, Psychological--drug therapy
Time Factors