Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells.

Yang, Jianhong

Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells. [electronic resource] - Scientific reports Jan 2015 - 7697 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2045-2322

10.1038/srep07697 doi


Antineoplastic Agents--toxicity
Apoptosis
Apoptosis Regulatory Proteins--antagonists & inhibitors
Autophagy--drug effects
Autophagy-Related Protein 7
Beclin-1
Carcinoma, Non-Small-Cell Lung--metabolism
Cell Line, Tumor
Cell Survival--drug effects
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Lung Neoplasms--metabolism
Membrane Proteins--antagonists & inhibitors
Microtubule-Associated Proteins--metabolism
Proto-Oncogene Proteins c-akt--metabolism
RNA Interference
RNA, Small Interfering--metabolism
Signal Transduction--drug effects
Sirolimus--toxicity
TOR Serine-Threonine Kinases--metabolism
Ubiquitin-Activating Enzymes--antagonists & inhibitors
Xanthones--chemistry