A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.
Yang, Pei-Chi
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. [electronic resource] - The Journal of physiology Mar 2015 - 1429-42 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1469-7793
10.1113/jphysiol.2014.279554 doi
Action Potentials--drug effects
Animals
Female
Guinea Pigs
Heart Ventricles--cytology
Male
Models, Neurological
Myocytes, Cardiac--drug effects
Protein Binding
Pyridines--pharmacology
Sodium Channel Blockers--pharmacology
Sodium Channels--metabolism
Triazoles--pharmacology
Ventricular Function--drug effects
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. [electronic resource] - The Journal of physiology Mar 2015 - 1429-42 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1469-7793
10.1113/jphysiol.2014.279554 doi
Action Potentials--drug effects
Animals
Female
Guinea Pigs
Heart Ventricles--cytology
Male
Models, Neurological
Myocytes, Cardiac--drug effects
Protein Binding
Pyridines--pharmacology
Sodium Channel Blockers--pharmacology
Sodium Channels--metabolism
Triazoles--pharmacology
Ventricular Function--drug effects