Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.

Funato, Kosuke

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. [electronic resource] - Science (New York, N.Y.) Dec 2014 - 1529-33 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1095-9203

10.1126/science.1253799 doi


Animals
Antineoplastic Agents--pharmacology
Brain Stem Neoplasms--genetics
Cell Transformation, Neoplastic--genetics
Child
Drug Screening Assays, Antitumor
Embryonic Stem Cells--metabolism
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genome-Wide Association Study
Glioma--genetics
Histones--genetics
Humans
Mice
Models, Genetic
Neural Stem Cells--metabolism
Proto-Oncogene Proteins--antagonists & inhibitors
Tumor Suppressor Protein p53--genetics