A novel approach for quantitation of nonderivatized sialic acid in protein therapeutics using hydrophilic interaction chromatographic separation and nano quantity analyte detection.

Chemmalil, Letha

A novel approach for quantitation of nonderivatized sialic acid in protein therapeutics using hydrophilic interaction chromatographic separation and nano quantity analyte detection. [electronic resource] - Journal of pharmaceutical sciences Jan 2015 - 15-24 p. digital

Publication Type: Comparative Study; Evaluation Study; Journal Article

1520-6017

10.1002/jps.24093 doi


Aerosols
Algorithms
Analytic Sample Preparation Methods
Chemistry, Pharmaceutical--methods
Chromatography, High Pressure Liquid
Drug Contamination--prevention & control
Glycoproteins--chemistry
Hydrophobic and Hydrophilic Interactions
Limit of Detection
Models, Molecular
N-Acetylneuraminic Acid--analysis
Nanotechnology
Nephelometry and Turbidimetry
Particle Size
Recombinant Proteins--chemistry
Refractometry
Reproducibility of Results