A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.

Bedard, Philippe L

A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Feb 2015 - 730-8 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

1557-3265

10.1158/1078-0432.CCR-14-1814 doi


Adult
Aged
Aged, 80 and over
Aminopyridines--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--administration & dosage
Disease-Free Survival
Dose-Response Relationship, Drug
Female
Humans
Male
Maximum Tolerated Dose
Middle Aged
Morpholines--administration & dosage
Neoplasms--drug therapy
Pyridones--administration & dosage
Pyrimidinones--administration & dosage