Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAF(V⁶⁰⁰E) inhibitors.

Zhao, Meng-Yue

Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAF(V⁶⁰⁰E) inhibitors. [electronic resource] - Bioorganic & medicinal chemistry Jan 2015 - 46-54 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3391

10.1016/j.bmc.2014.11.029 doi


Cell Line, Tumor
Cell Proliferation--drug effects
Humans
MCF-7 Cells
Molecular Docking Simulation
Protein Kinase Inhibitors--chemical synthesis
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Pyrazoles--chemical synthesis
Quantitative Structure-Activity Relationship
Thiazoles--chemical synthesis