Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Bisson, Joseph A

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. [electronic resource] - Developmental biology Feb 2015 - 80-96 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1095-564X

10.1016/j.ydbio.2014.11.015 doi


Animals
Caspases--metabolism
Cell Line
Embryonic Stem Cells--cytology
Female
Gene Expression Regulation, Developmental
Heart--embryology
Male
Mice
Mice, Transgenic
Mutation
Myocardium--cytology
Phosphorylation
Polymerase Chain Reaction
Pregnancy
Pregnancy, Animal
Proto-Oncogene Proteins c-akt--metabolism
Signal Transduction
Stem Cells--cytology
Wnt Proteins--metabolism
Wnt Signaling Pathway--physiology
Wnt-5a Protein