Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.

Littlefield, Peter

Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations. [electronic resource] - Science signaling Dec 2014 - ra114 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1937-9145

10.1126/scisignal.2005786 doi


Cloning, Molecular
Crystallization
Dimerization
ErbB Receptors--chemistry
Humans
Models, Molecular
Molecular Dynamics Simulation
Mutagenesis, Site-Directed
Mutation--genetics
Protein Structure, Tertiary
Receptor, ErbB-3--chemistry
Signal Transduction--genetics