HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction.
Kang, Hyo Jin
HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction. [electronic resource] - Scientific reports Dec 2014 - 7201 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep07201 doi
Antioxidant Response Elements--genetics
Breast Neoplasms--drug therapy
Cell Line
DNA-Binding Proteins--genetics
Doxorubicin--pharmacology
Drug Resistance, Neoplasm--genetics
Female
Gene Expression Regulation, Neoplastic--drug effects
HEK293 Cells
Heme Oxygenase-1--genetics
Humans
MCF-7 Cells
Multidrug Resistance-Associated Proteins--genetics
NF-E2-Related Factor 2--genetics
Paraquat--pharmacology
Receptor, ErbB-2--genetics
Transcription, Genetic--drug effects
Transcriptional Activation--drug effects
Tumor Cells, Cultured
Up-Regulation--drug effects
HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction. [electronic resource] - Scientific reports Dec 2014 - 7201 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep07201 doi
Antioxidant Response Elements--genetics
Breast Neoplasms--drug therapy
Cell Line
DNA-Binding Proteins--genetics
Doxorubicin--pharmacology
Drug Resistance, Neoplasm--genetics
Female
Gene Expression Regulation, Neoplastic--drug effects
HEK293 Cells
Heme Oxygenase-1--genetics
Humans
MCF-7 Cells
Multidrug Resistance-Associated Proteins--genetics
NF-E2-Related Factor 2--genetics
Paraquat--pharmacology
Receptor, ErbB-2--genetics
Transcription, Genetic--drug effects
Transcriptional Activation--drug effects
Tumor Cells, Cultured
Up-Regulation--drug effects