Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.

Bartolini, D

Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation. [electronic resource] - Free radical biology & medicine Jan 2015 - 56-65 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1873-4596

10.1016/j.freeradbiomed.2014.10.008 doi


Animals
Antioxidants--metabolism
Apoptosis--drug effects
Azoles--pharmacology
Biomimetics
Cell Proliferation--drug effects
Cells, Cultured
Chemistry, Pharmaceutical
Drug Compounding
Glutathione--metabolism
Glutathione Peroxidase--chemistry
Glutathione S-Transferase pi--antagonists & inhibitors
Humans
Hydrogen Peroxide--metabolism
Isoindoles
K562 Cells
Kinetics
MCF-7 Cells
Mice
Mice, Knockout
Organoselenium Compounds--pharmacology
Oxidative Stress--drug effects
Polyesters--chemistry
Reactive Oxygen Species--metabolism
Selenium Compounds--pharmacology
Sulfhydryl Compounds--metabolism