A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.

Brehme, Marc

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. [electronic resource] - Cell reports Nov 2014 - 1135-50 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2014.09.042 doi


Aging--metabolism
Animals
Brain--growth & development
Caenorhabditis elegans--growth & development
Disease Models, Animal
Gene Regulatory Networks
Humans
Huntingtin Protein
Models, Biological
Molecular Chaperones--metabolism
Nerve Tissue Proteins--metabolism
Neurodegenerative Diseases--complications
Protein Aggregation, Pathological--metabolism
Protein Folding
Proteostasis Deficiencies--complications