Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis.

Rauthu, Subhash R

Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis. [electronic resource] - Chembiochem : a European journal of chemical biology Jan 2015 - 126-39 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1439-7633

10.1002/cbic.201402474 doi


Acetylglucosamine--chemistry
Alkynes--chemistry
Amino Sugars--chemical synthesis
Azides--chemistry
Blood Proteins
Carbohydrate Sequence
Catalysis
Cycloaddition Reaction
Galectin 1--antagonists & inhibitors
Galectin 3--antagonists & inhibitors
Galectins--antagonists & inhibitors
Glycosides--chemical synthesis
Humans
Hydrophobic and Hydrophilic Interactions
Ligands
Models, Molecular
Molecular Sequence Data
Nitrophenylgalactosides--chemistry
Protein Binding
Structure-Activity Relationship
Triazoles--chemistry