Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

Flanagan, Mark E

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors. [electronic resource] - Journal of medicinal chemistry Dec 2014 - 10072-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm501412a doi


Drug Design
Enzyme Inhibitors--chemistry
Glutathione--chemistry
Humans
Kinetics
Mass Spectrometry
Nuclear Magnetic Resonance, Biomolecular
Pharmaceutical Preparations--chemistry