The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.

Umapathy, Ganesh

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. [electronic resource] - Science signaling Oct 2014 - ra102 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1937-9145

10.1126/scisignal.2005470 doi


Anaplastic Lymphoma Kinase
Animals
Cell Line, Tumor
DNA Primers--genetics
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic--genetics
Green Fluorescent Proteins
Humans
Image Processing, Computer-Assisted
Immunoblotting
Immunohistochemistry
Immunoprecipitation
Magnetic Resonance Imaging
Mitogen-Activated Protein Kinase 7--genetics
N-Myc Proto-Oncogene Protein
Neuroblastoma--metabolism
Nuclear Proteins--metabolism
Oncogene Proteins--metabolism
PC12 Cells
RNA Interference
Rats
Real-Time Polymerase Chain Reaction
Receptor Protein-Tyrosine Kinases--metabolism