Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme.
Zou, Taisong
Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme. [electronic resource] - Molecular biology and evolution Jan 2015 - 132-43 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1537-1719
10.1093/molbev/msu281 doi
Anti-Bacterial Agents--metabolism
Bacteria--enzymology
Catalytic Domain
Evolution, Molecular
Molecular Dynamics Simulation
Mutation
Principal Component Analysis
Protein Structure, Tertiary
Substrate Specificity
beta-Lactamases--chemistry
Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme. [electronic resource] - Molecular biology and evolution Jan 2015 - 132-43 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1537-1719
10.1093/molbev/msu281 doi
Anti-Bacterial Agents--metabolism
Bacteria--enzymology
Catalytic Domain
Evolution, Molecular
Molecular Dynamics Simulation
Mutation
Principal Component Analysis
Protein Structure, Tertiary
Substrate Specificity
beta-Lactamases--chemistry