PKA reduces the rat and human KCa3.1 current, CaM binding, and Ca2+ signaling, which requires Ser332/334 in the CaM-binding C terminus.

Wong, Raymond

PKA reduces the rat and human KCa3.1 current, CaM binding, and Ca2+ signaling, which requires Ser332/334 in the CaM-binding C terminus. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Oct 2014 - 13371-83 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.1008-14.2014 doi


Animals
Animals, Newborn
Benzimidazoles--pharmacology
Calcium--metabolism
Calcium Channel Agonists--pharmacology
Calcium Signaling--physiology
Calcium-Calmodulin-Dependent Protein Kinases--metabolism
Calmodulin--metabolism
Cells, Cultured
Enzyme Inhibitors--pharmacology
Female
HEK293 Cells
Humans
Intermediate-Conductance Calcium-Activated Potassium Channels--genetics
Male
Membrane Potentials--drug effects
Protein Binding--drug effects
Protein Kinases--genetics
Rats
Rats, Sprague-Dawley
Serine--metabolism