Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome.

Buckley, Maria M

Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome. [electronic resource] - The Journal of physiology Dec 2014 - 5235-50 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1469-7793

10.1113/jphysiol.2014.279968 doi


Adolescent
Adult
Aged
Animals
Antibodies, Monoclonal--administration & dosage
Case-Control Studies
Disease Models, Animal
Enteric Nervous System--physiopathology
Female
Gastrointestinal Motility--physiology
Humans
Interleukin-6--physiology
Irritable Bowel Syndrome--etiology
Male
Middle Aged
Myenteric Plexus--physiopathology
Neuroimmunomodulation--physiology
Neurosecretory Systems--physiopathology
Pain Threshold--drug effects
Pyrimidines--administration & dosage
Pyrroles--administration & dosage
Rats
Rats, Inbred WKY
Rats, Sprague-Dawley
Receptors, Corticotropin-Releasing Hormone--antagonists & inhibitors
Receptors, Interleukin-6--antagonists & inhibitors
Visceral Pain--etiology
Young Adult
CRF Receptor, Type 1