A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.

Kassa, Jiri

A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice. [electronic resource] - Basic & clinical pharmacology & toxicology Apr 2015 - 367-71 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1742-7843

10.1111/bcpt.12327 doi


Animals
Antidotes--therapeutic use
Atropine--pharmacology
Chemical Warfare Agents--toxicity
Cholinesterase Inhibitors--toxicity
Cholinesterase Reactivators--therapeutic use
Injections, Intramuscular
Lethal Dose 50
Male
Mice
Organophosphates--toxicity
Oximes--therapeutic use
Parasympatholytics--pharmacology
Pyridinium Compounds--therapeutic use
Rats
Rats, Wistar
Trimedoxime--therapeutic use