Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells.

Obakan, Pinar

Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells. [electronic resource] - The Prostate Dec 2014 - 1622-33 p. digital

Publication Type: Journal Article

1097-0045

10.1002/pros.22879 doi


Androgens--physiology
Apoptosis--drug effects
Brassinosteroids--pharmacology
Caspases--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Humans
Male
Metabolism--physiology
Polyamines--metabolism
Prostatic Neoplasms--metabolism
Reactive Oxygen Species--metabolism
Receptors, Androgen--metabolism
Signal Transduction--drug effects
Steroids, Heterocyclic--pharmacology
Tumor Suppressor Protein p53--physiology