Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells.

Koehler, Bruno Christian

Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. [electronic resource] - PloS one 2014 - e106571 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0106571 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Biphenyl Compounds--pharmacology
Cadherins--metabolism
Cell Cycle--drug effects
Cell Line, Tumor
Cell Movement--drug effects
Cell Proliferation--drug effects
Colorectal Neoplasms--genetics
Cyclin D1--genetics
Cyclin-Dependent Kinase Inhibitor p21--genetics
Cyclin-Dependent Kinase Inhibitor p27--genetics
G1 Phase Cell Cycle Checkpoints--drug effects
Gene Expression
Humans
Indoles
Nitrophenols--pharmacology
Piperazines--pharmacology
Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors
Pyrroles--pharmacology
Sulfonamides--pharmacology