Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.

Cantley, Jennifer L

Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. [electronic resource] - American journal of physiology. Endocrinology and metabolism Nov 2014 - E773-83 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

1522-1555

10.1152/ajpendo.00148.2014 doi


Adipose Tissue--drug effects
Animals
Biological Transport--drug effects
Diet, High-Fat--adverse effects
Enzyme Inhibitors--therapeutic use
Gene Expression Regulation, Enzymologic--drug effects
Glucose Intolerance--drug therapy
Glucose Transporter Type 4--agonists
Insulin Resistance
Intracellular Signaling Peptides and Proteins--agonists
Intramolecular Oxidoreductases--genetics
Lipocalins--agonists
Liver--drug effects
Male
Muscle, Skeletal--drug effects
Nuclear Receptor Coactivator 1--antagonists & inhibitors
Oligodeoxyribonucleotides, Antisense--therapeutic use
Phosphoenolpyruvate Carboxykinase (GTP)--genetics
Prostaglandin D2--blood
Protein Interaction Domains and Motifs
Proteolysis--drug effects
Rats, Sprague-Dawley