Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis.
Chen, Nanzheng
Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis. [electronic resource] - International journal of molecular medicine Oct 2014 - 1110-6 p. digital
Publication Type: Journal Article
1791-244X
10.3892/ijmm.2014.1867 doi
Animals
Cell Proliferation--drug effects
Collagen Type I--metabolism
Curcumin--pharmacology
Endoplasmic Reticulum Stress--drug effects
Ethanol
Fibronectins--metabolism
Hepatic Stellate Cells--drug effects
Liver--drug effects
Liver Cirrhosis--drug therapy
Male
Protective Agents--pharmacology
Rats, Sprague-Dawley
Signal Transduction--drug effects
Smad Proteins--metabolism
Transforming Growth Factor beta--metabolism
Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis. [electronic resource] - International journal of molecular medicine Oct 2014 - 1110-6 p. digital
Publication Type: Journal Article
1791-244X
10.3892/ijmm.2014.1867 doi
Animals
Cell Proliferation--drug effects
Collagen Type I--metabolism
Curcumin--pharmacology
Endoplasmic Reticulum Stress--drug effects
Ethanol
Fibronectins--metabolism
Hepatic Stellate Cells--drug effects
Liver--drug effects
Liver Cirrhosis--drug therapy
Male
Protective Agents--pharmacology
Rats, Sprague-Dawley
Signal Transduction--drug effects
Smad Proteins--metabolism
Transforming Growth Factor beta--metabolism