A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism.

Hasbi, Ahmed

A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism. [electronic resource] - FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov 2014 - 4806-20 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1530-6860

10.1096/fj.14-254037 doi


Animals
Brain--metabolism
Calcium Signaling--physiology
Dopamine--metabolism
Dopamine D2 Receptor Antagonists--pharmacology
Male
Neurons--drug effects
Peptides--metabolism
Protein Multimerization
Rats, Sprague-Dawley
Receptors, Dopamine D1--antagonists & inhibitors
Receptors, Dopamine D2--metabolism