Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Laufer, Radoslaw

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. [electronic resource] - Bioorganic & medicinal chemistry Sep 2014 - 4968-97 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3391

10.1016/j.bmc.2014.06.027 doi


Amides--chemical synthesis
Benzeneacetamides--chemical synthesis
Cell Cycle Proteins--antagonists & inhibitors
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Discovery
Humans
Indazoles--chemical synthesis
Models, Molecular
Molecular Structure
Protein Kinase Inhibitors--chemical synthesis
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
Structure-Activity Relationship