Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.

Der Sarkissian, S

Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1. [electronic resource] - British journal of pharmacology Dec 2014 - 5265-79 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.12838 doi


Animals
Cardiotonic Agents--pharmacology
Cell Line
Cell Survival--drug effects
DNA-Binding Proteins--metabolism
Female
HSP70 Heat-Shock Proteins--metabolism
Heat Shock Transcription Factors
Heat-Shock Response--drug effects
Heme Oxygenase (Decyclizing)--biosynthesis
Hypoxia--metabolism
MAP Kinase Signaling System--drug effects
Myocardial Ischemia--drug therapy
Myocardium--pathology
Oncogene Protein v-akt--metabolism
Pentacyclic Triterpenes
Phosphatidylinositol 3-Kinases--metabolism
Rats, Sprague-Dawley
Reactive Oxygen Species--metabolism
Transcription Factors--metabolism
Triterpenes--pharmacology
Up-Regulation