Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.

Belcaid, Zineb

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. [electronic resource] - PloS one 2014 - e101764 p. digital

Publication Type: Journal Article

1932-6203

10.1371/journal.pone.0101764 doi


Animals
Antibodies--therapeutic use
CD4-Positive T-Lymphocytes--metabolism
CD8-Positive T-Lymphocytes--metabolism
CTLA-4 Antigen--antagonists & inhibitors
Cell Line, Tumor
Female
Glioma--drug therapy
Mice
Mice, Inbred C57BL
Tumor Necrosis Factor Receptor Superfamily, Member 9--agonists