Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells.

Bachour-El Azzi, Pamela

Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2014 - 1556-66 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-009X

10.1124/dmd.114.058123 doi


Actins--genetics
Bile Acids and Salts--genetics
C-Reactive Protein--genetics
Cell Line
Chlorpromazine--adverse effects
Cholestasis--chemically induced
Cytochrome P-450 CYP1A2--genetics
Cytochrome P-450 CYP3A--genetics
Down-Regulation--genetics
Humans
Inflammation--genetics
Interleukins--genetics
Organic Anion Transporters, Sodium-Dependent--genetics
Oxidative Stress--genetics
RNA, Messenger--genetics
Symporters--genetics
Taurocholic Acid--genetics