Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam, Ramanjaneyulu

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. [electronic resource] - EMBO reports Sep 2014 - 982-90 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1469-3178

10.15252/embr.201438463 doi


Apoptosis--genetics
Autophagy--genetics
Bone Marrow Cells--metabolism
Carrier Proteins--biosynthesis
Caspase 8--biosynthesis
Cells, Cultured
Peptidyl-Prolyl Isomerase F
Cyclophilins--antagonists & inhibitors
Humans
Inflammasomes--metabolism
Interleukin-1beta--biosynthesis
Mitochondria--metabolism
Mitophagy--genetics
NLR Family, Pyrin Domain-Containing 3 Protein
Toll-Like Receptors--metabolism
Ubiquitin-Protein Ligases--genetics