Correlation between the glycan variations and defibrinogenating activities of acutobin and its recombinant glycoforms.

Wang, Ying-Ming

Correlation between the glycan variations and defibrinogenating activities of acutobin and its recombinant glycoforms. [electronic resource] - PloS one 2014 - e100354 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0100354 doi


Animals
Biocatalysis--drug effects
CHO Cells
Cricetinae
Cricetulus
Crotalid Venoms--chemistry
Enzyme Stability--drug effects
Fibrin Fibrinogen Degradation Products--metabolism
Fibrinolysis--drug effects
Fibrinolytic Agents--pharmacology
Glycosylation--drug effects
HEK293 Cells
Humans
Hydrolysis
Kinetics
Mice
Molecular Weight
Peptide Mapping
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase--metabolism
Peptides--chemistry
Polysaccharides--chemistry
Protein Isoforms--chemistry
Rabbits
Recombinant Proteins--pharmacology
Serum Globulins--metabolism
Substrate Specificity--drug effects
Thrombin--chemistry