Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.

Hanson, Jesse E

Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Jun 2014 - 8277-88 p. digital

Publication Type: Journal Article

1529-2401

10.1523/JNEUROSCI.5106-13.2014 doi


Alzheimer Disease--complications
Amyloid beta-Peptides--metabolism
Amyloid beta-Protein Precursor--genetics
Animals
Attention Deficit and Disruptive Behavior Disorders--chemically induced
Behavior, Animal--drug effects
Disease Models, Animal
Female
HEK293 Cells
Humans
In Vitro Techniques
Male
Maze Learning--drug effects
Membrane Potentials--drug effects
Memory Disorders--etiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation--genetics
Piperidines--pharmacology
Synapses--pathology