Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition.

Fraccarollo, Daniela

Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition. [electronic resource] - Basic research in cardiology Jul 2014 - 421 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1435-1803

10.1007/s00395-014-0421-1 doi


Angiotensin-Converting Enzyme Inhibitors--pharmacology
Animals
Cardiotonic Agents--pharmacology
Cell Communication
Cells, Cultured
Disease Models, Animal
Drug Therapy, Combination
Enzyme Activation
Enzyme Activators--pharmacology
Extracellular Matrix--metabolism
Fibrosis
Guanylate Cyclase--metabolism
Heart Failure--drug therapy
Hemodynamics--drug effects
Humans
Male
Mice
Mitochondria, Heart--drug effects
Myocardial Contraction--drug effects
Myocardial Infarction--complications
Myocytes, Cardiac--drug effects
Myofibroblasts--drug effects
Nitric Oxide--metabolism
Nitric Oxide Synthase Type III--metabolism
Oxidative Stress--drug effects
Ramipril--pharmacology
Rats, Wistar
Receptors, Cytoplasmic and Nuclear--metabolism
Soluble Guanylyl Cyclase
Sulfonamides--pharmacology
Superoxides--metabolism
Time Factors
Ventricular Function, Left--drug effects
Ventricular Remodeling--drug effects
ortho-Aminobenzoates--pharmacology