Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.

Goswami, S

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. [electronic resource] - Clinical pharmacology and therapeutics Sep 2014 - 370-9 p. digital

Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural

1532-6535

10.1038/clpt.2014.109 doi


Adult
Aged
Aged, 80 and over
Biomarkers--metabolism
Diabetes Mellitus, Type 2--blood
Female
Genome-Wide Association Study
Glycated Hemoglobin--metabolism
Hepatocyte Nuclear Factor 4--genetics
Homozygote
Humans
Hypoglycemic Agents--administration & dosage
Male
Metformin--administration & dosage
Middle Aged
Models, Biological
Multivariate Analysis
PPAR alpha--genetics
Pharmacogenetics
Phenotype
Polymorphism, Single Nucleotide
Retrospective Studies
Sp1 Transcription Factor--genetics
Transcription Factors--genetics
Treatment Outcome
United States
Young Adult