Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer.

Wang, Y

Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. [electronic resource] - Cell death & disease May 2014 - e1227 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/cddis.2014.186 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Cycle Checkpoints--drug effects
Cell Line, Tumor
Cell Movement--drug effects
Cyclin B1--genetics
Disease-Free Survival
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition--drug effects
Gefitinib
HEK293 Cells
Humans
Kaplan-Meier Estimate
Lung Neoplasms--drug therapy
Mice
Mice, Nude
MicroRNAs--metabolism
Neoplasm Invasiveness
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins--genetics
Quinazolines--pharmacology
RNA Interference
Receptor Protein-Tyrosine Kinases--metabolism
Time Factors
Transfection
Tumor Burden--drug effects
Wnt Proteins--genetics
Wnt-5a Protein
Xenograft Model Antitumor Assays
Axl Receptor Tyrosine Kinase