Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons.
Walsh, Keifer P
Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. [electronic resource] - PloS one 2014 - e95995 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0095995 doi
Actin Depolymerizing Factors--metabolism
Actins--metabolism
Amyloid beta-Peptides--metabolism
Animals
Cells, Cultured
Dactinomycin--pharmacology
Female
Gene Expression Regulation--drug effects
Glutamic Acid--pharmacology
Hippocampus--cytology
Humans
Inflammation--metabolism
Mice
NADPH Oxidases--metabolism
Neurites--metabolism
PrPC Proteins--genetics
Rats
Signal Transduction
Synaptic Transmission--drug effects
Tumor Necrosis Factor-alpha--metabolism
Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. [electronic resource] - PloS one 2014 - e95995 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0095995 doi
Actin Depolymerizing Factors--metabolism
Actins--metabolism
Amyloid beta-Peptides--metabolism
Animals
Cells, Cultured
Dactinomycin--pharmacology
Female
Gene Expression Regulation--drug effects
Glutamic Acid--pharmacology
Hippocampus--cytology
Humans
Inflammation--metabolism
Mice
NADPH Oxidases--metabolism
Neurites--metabolism
PrPC Proteins--genetics
Rats
Signal Transduction
Synaptic Transmission--drug effects
Tumor Necrosis Factor-alpha--metabolism