Dynamics and hydration explain failed functional transformation in dehalogenase design.

Sykora, Jan

Dynamics and hydration explain failed functional transformation in dehalogenase design. [electronic resource] - Nature chemical biology Jun 2014 - 428-30 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1552-4469

10.1038/nchembio.1502 doi


Amino Acid Sequence
Catalysis
Catalytic Domain
Crystallography, X-Ray
Hydrocarbons, Brominated--chemistry
Hydrolases--chemistry
Molecular Dynamics Simulation
Molecular Sequence Data
Mutagenesis, Site-Directed
Protein Conformation
Protein Engineering
Spectrometry, Fluorescence
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Stereoisomerism
Water--chemistry