Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria.

Nita, Iulia I

Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria. [electronic resource] - FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 2014 - 3301-12 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1530-6860

10.1096/fj.13-248161 doi


Adenosine Triphosphate--biosynthesis
Animals
Biological Transport, Active--drug effects
Calcium--metabolism
Calcium Channel Blockers--adverse effects
Calcium Channels--physiology
Calcium Signaling--drug effects
Cell Membrane--metabolism
Cells, Cultured
Endoplasmic Reticulum--metabolism
Female
Glucose--physiology
Insulin--metabolism
Insulin Secretion
Islets of Langerhans--drug effects
Lithium--metabolism
Membrane Potential, Mitochondrial--physiology
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mitochondria--metabolism
Oxidative Phosphorylation
Patch-Clamp Techniques
Sodium--metabolism
Sodium-Calcium Exchanger--antagonists & inhibitors
Specific Pathogen-Free Organisms
Tetrodotoxin--pharmacology