Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition.

Murdoch, Colin E

Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition. [electronic resource] - Journal of the American College of Cardiology Jun 2014 - 2734-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1558-3597

10.1016/j.jacc.2014.02.572 doi


Animals
Cardiomegaly--enzymology
Cells, Cultured
Endothelium, Vascular--enzymology
Fibrosis--enzymology
Heart Failure, Diastolic--enzymology
Humans
Inflammation Mediators--physiology
Male
Membrane Glycoproteins--genetics
Mesenchymal Stem Cells--enzymology
Mice
Mice, Transgenic
NADPH Oxidase 2
NADPH Oxidases--genetics
Ventricular Dysfunction, Left--enzymology