A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2168-6157
10.1001/jamaneurol.2014.131 doi
Aged
Antioxidants--administration & dosage
Dose-Response Relationship, Drug
Double-Blind Method
Early Diagnosis
Female
Humans
Male
Middle Aged
Parkinson Disease--diagnosis
Prospective Studies
Treatment Outcome
Ubiquinone--administration & dosage
A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
APA
Beal M. F., Oakes D., Shoulson I., Henchcliffe C., Galpern W. R., Haas R., Juncos J. L., Nutt J. G., Voss T. S., Ravina B., Shults C. M., Helles K., Snively V., Lew M. F., Griebner B., Watts A., Gao S., Pourcher E., Bond L., Kompoliti K., Agarwal P., Sia C., Jog M., Cole L., Sultana M., Kurlan R., Richard I., Deeley C., Waters C. H., Figueroa A., Arkun A., Brodsky M., Ondo W. G., Hunter C. B., Jimenez-Shahed J., Palao A., Miyasaki J. M., So J., Tetrud J., Reys L., Smith K., Singer C., Blenke A., Russell D. S., Cotto C., Friedman J. H., Lannon M., Zhang L., Drasby E., Kumar R., Subramanian T., Ford D. S., Grimes D. A., Cote D., Conway J., Siderowf A. D., Evatt M. L., Sommerfeld B., Lieberman A. N., Okun M. S., Rodriguez R. L., Merritt S., Swartz C. L., Martin W. R. W., King P., Stover N., Guthrie S., Watts R. L., Ahmed A., Fernandez H. H., Winters A., Mari Z., Dawson T. M., Dunlop B., Feigin A. S., Shannon B., Nirenberg M. J., Ogg M., Ellias S. A., Thomas C., Frei K., Bodis-Wollner I., Glazman S., Mayer T., Hauser R. A., Pahwa R., Langhammer A., Ranawaya R., Derwent L., Sethi K. D., Farrow B., Prakash R., Litvan I., Robinson A., Sahay A., Gartner M., Hinson V. K., Markind S., Pelikan M., Perlmutter J. S., Hartlein J., Molho E., Evans S., Adler C. H., Duffy A., Lind M., Elmer L., Davis K., Spears J., Wilson S., Leehey M. A., Hermanowicz N., Niswonger S., Shill H. A., Obradov S., Rajput A., Cowper M., Lessig S., Song D., Fontaine D., Zadikoff C., Williams K., Blindauer K. A., Bergholte J., Propsom C. S., Stacy M. A., Field J., Mihaila D., Chilton M., Uc E. Y., Sieren J., Simon D. K., Kraics L., Silver A., Boyd J. T., Hamill R. W., Ingvoldstad C., Young J., Thomas K., Kostyk S. K., Wojcieszek J., Pfeiffer R. F., Panisset M., Beland M., Reich S. G., Cines M., Zappala N., Rivest J., Zweig R., Lumina L. P., Hilliard C. L., Grill S., Kellermann M., Tuite P., Rolandelli S., Kang U. J., Young J., Rao J., Cook M. M., Severt L. & Boyar K. (20140707). A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. : JAMA neurology.
Chicago
Beal M Flint, Oakes David, Shoulson Ira, Henchcliffe Claire, Galpern Wendy R, Haas Richard, Juncos Jorge L, Nutt John G, Voss Tiffini Smith, Ravina Bernard, Shults Clifford M, Helles Karen, Snively Victoria, Lew Mark F, Griebner Brian, Watts Arthur, Gao Shan, Pourcher Emmanuelle, Bond Louisette, Kompoliti Katie, Agarwal Pinky, Sia Cherissa, Jog Mandar, Cole Linda, Sultana Munira, Kurlan Roger, Richard Irene, Deeley Cheryl, Waters Cheryl H, Figueroa Angel, Arkun Ani, Brodsky Matthew, Ondo William G, Hunter Christine B, Jimenez-Shahed Joohi, Palao Alicia, Miyasaki Janis M, So Julie, Tetrud James, Reys Liza, Smith Katharine, Singer Carlos, Blenke Anita, Russell David S, Cotto Candace, Friedman Joseph H, Lannon Margaret, Zhang Lin, Drasby Edward, Kumar Rajeev, Subramanian Thyagarajan, Ford Donna Stuppy, Grimes David A, Cote Diane, Conway Jennifer, Siderowf Andrew D, Evatt Marian Leslie, Sommerfeld Barbara, Lieberman Abraham N, Okun Michael S, Rodriguez Ramon L, Merritt Stacy, Swartz Camille Louise, Martin W R Wayne, King Pamela, Stover Natividad, Guthrie Stephanie, Watts Ray L, Ahmed Anwar, Fernandez Hubert H, Winters Adrienna, Mari Zoltan, Dawson Ted M, Dunlop Becky, Feigin Andrew S, Shannon Barbara, Nirenberg Melissa Jill, Ogg Mattson, Ellias Samuel A, Thomas Cathi-Ann, Frei Karen, Bodis-Wollner Ivan, Glazman Sofya, Mayer Thomas, Hauser Robert A, Pahwa Rajesh, Langhammer April, Ranawaya Ranjit, Derwent Lorelei, Sethi Kapil D, Farrow Buff, Prakash Rajan, Litvan Irene, Robinson Annette, Sahay Alok, Gartner Maureen, Hinson Vanessa K, Markind Samuel, Pelikan Melisa, Perlmutter Joel S, Hartlein Johanna, Molho Eric, Evans Sharon, Adler Charles H, Duffy Amy, Lind Marlene, Elmer Lawrence, Davis Kathy, Spears Julia, Wilson Stephanie, Leehey Maureen A, Hermanowicz Neal, Niswonger Shari, Shill Holly A, Obradov Sanja, Rajput Alex, Cowper Marilyn, Lessig Stephanie, Song David, Fontaine Deborah, Zadikoff Cindy, Williams Karen, Blindauer Karen A, Bergholte Jo, Propsom Clara Schindler, Stacy Mark A, Field Joanne, Mihaila Dragos, Chilton Mark, Uc Ergun Y, Sieren Jeri, Simon David K, Kraics Lauren, Silver Althea, Boyd James T, Hamill Robert W, Ingvoldstad Christopher, Young Jennifer, Thomas Karen, Kostyk Sandra K, Wojcieszek Joanne, Pfeiffer Ronald F, Panisset Michel, Beland Monica, Reich Stephen G, Cines Michelle, Zappala Nancy, Rivest Jean, Zweig Richard, Lumina L Pepper, Hilliard Colette Lynn, Grill Stephen, Kellermann Marye, Tuite Paul, Rolandelli Susan, Kang Un Jung, Young Joan, Rao Jayaraman, Cook Maureen M, Severt Lawrence and Boyar Karyn. 20140707. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. : JAMA neurology.
Harvard
Beal M. F., Oakes D., Shoulson I., Henchcliffe C., Galpern W. R., Haas R., Juncos J. L., Nutt J. G., Voss T. S., Ravina B., Shults C. M., Helles K., Snively V., Lew M. F., Griebner B., Watts A., Gao S., Pourcher E., Bond L., Kompoliti K., Agarwal P., Sia C., Jog M., Cole L., Sultana M., Kurlan R., Richard I., Deeley C., Waters C. H., Figueroa A., Arkun A., Brodsky M., Ondo W. G., Hunter C. B., Jimenez-Shahed J., Palao A., Miyasaki J. M., So J., Tetrud J., Reys L., Smith K., Singer C., Blenke A., Russell D. S., Cotto C., Friedman J. H., Lannon M., Zhang L., Drasby E., Kumar R., Subramanian T., Ford D. S., Grimes D. A., Cote D., Conway J., Siderowf A. D., Evatt M. L., Sommerfeld B., Lieberman A. N., Okun M. S., Rodriguez R. L., Merritt S., Swartz C. L., Martin W. R. W., King P., Stover N., Guthrie S., Watts R. L., Ahmed A., Fernandez H. H., Winters A., Mari Z., Dawson T. M., Dunlop B., Feigin A. S., Shannon B., Nirenberg M. J., Ogg M., Ellias S. A., Thomas C., Frei K., Bodis-Wollner I., Glazman S., Mayer T., Hauser R. A., Pahwa R., Langhammer A., Ranawaya R., Derwent L., Sethi K. D., Farrow B., Prakash R., Litvan I., Robinson A., Sahay A., Gartner M., Hinson V. K., Markind S., Pelikan M., Perlmutter J. S., Hartlein J., Molho E., Evans S., Adler C. H., Duffy A., Lind M., Elmer L., Davis K., Spears J., Wilson S., Leehey M. A., Hermanowicz N., Niswonger S., Shill H. A., Obradov S., Rajput A., Cowper M., Lessig S., Song D., Fontaine D., Zadikoff C., Williams K., Blindauer K. A., Bergholte J., Propsom C. S., Stacy M. A., Field J., Mihaila D., Chilton M., Uc E. Y., Sieren J., Simon D. K., Kraics L., Silver A., Boyd J. T., Hamill R. W., Ingvoldstad C., Young J., Thomas K., Kostyk S. K., Wojcieszek J., Pfeiffer R. F., Panisset M., Beland M., Reich S. G., Cines M., Zappala N., Rivest J., Zweig R., Lumina L. P., Hilliard C. L., Grill S., Kellermann M., Tuite P., Rolandelli S., Kang U. J., Young J., Rao J., Cook M. M., Severt L. and Boyar K. (20140707). A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. : JAMA neurology.
MLA
Beal M Flint, Oakes David, Shoulson Ira, Henchcliffe Claire, Galpern Wendy R, Haas Richard, Juncos Jorge L, Nutt John G, Voss Tiffini Smith, Ravina Bernard, Shults Clifford M, Helles Karen, Snively Victoria, Lew Mark F, Griebner Brian, Watts Arthur, Gao Shan, Pourcher Emmanuelle, Bond Louisette, Kompoliti Katie, Agarwal Pinky, Sia Cherissa, Jog Mandar, Cole Linda, Sultana Munira, Kurlan Roger, Richard Irene, Deeley Cheryl, Waters Cheryl H, Figueroa Angel, Arkun Ani, Brodsky Matthew, Ondo William G, Hunter Christine B, Jimenez-Shahed Joohi, Palao Alicia, Miyasaki Janis M, So Julie, Tetrud James, Reys Liza, Smith Katharine, Singer Carlos, Blenke Anita, Russell David S, Cotto Candace, Friedman Joseph H, Lannon Margaret, Zhang Lin, Drasby Edward, Kumar Rajeev, Subramanian Thyagarajan, Ford Donna Stuppy, Grimes David A, Cote Diane, Conway Jennifer, Siderowf Andrew D, Evatt Marian Leslie, Sommerfeld Barbara, Lieberman Abraham N, Okun Michael S, Rodriguez Ramon L, Merritt Stacy, Swartz Camille Louise, Martin W R Wayne, King Pamela, Stover Natividad, Guthrie Stephanie, Watts Ray L, Ahmed Anwar, Fernandez Hubert H, Winters Adrienna, Mari Zoltan, Dawson Ted M, Dunlop Becky, Feigin Andrew S, Shannon Barbara, Nirenberg Melissa Jill, Ogg Mattson, Ellias Samuel A, Thomas Cathi-Ann, Frei Karen, Bodis-Wollner Ivan, Glazman Sofya, Mayer Thomas, Hauser Robert A, Pahwa Rajesh, Langhammer April, Ranawaya Ranjit, Derwent Lorelei, Sethi Kapil D, Farrow Buff, Prakash Rajan, Litvan Irene, Robinson Annette, Sahay Alok, Gartner Maureen, Hinson Vanessa K, Markind Samuel, Pelikan Melisa, Perlmutter Joel S, Hartlein Johanna, Molho Eric, Evans Sharon, Adler Charles H, Duffy Amy, Lind Marlene, Elmer Lawrence, Davis Kathy, Spears Julia, Wilson Stephanie, Leehey Maureen A, Hermanowicz Neal, Niswonger Shari, Shill Holly A, Obradov Sanja, Rajput Alex, Cowper Marilyn, Lessig Stephanie, Song David, Fontaine Deborah, Zadikoff Cindy, Williams Karen, Blindauer Karen A, Bergholte Jo, Propsom Clara Schindler, Stacy Mark A, Field Joanne, Mihaila Dragos, Chilton Mark, Uc Ergun Y, Sieren Jeri, Simon David K, Kraics Lauren, Silver Althea, Boyd James T, Hamill Robert W, Ingvoldstad Christopher, Young Jennifer, Thomas Karen, Kostyk Sandra K, Wojcieszek Joanne, Pfeiffer Ronald F, Panisset Michel, Beland Monica, Reich Stephen G, Cines Michelle, Zappala Nancy, Rivest Jean, Zweig Richard, Lumina L Pepper, Hilliard Colette Lynn, Grill Stephen, Kellermann Marye, Tuite Paul, Rolandelli Susan, Kang Un Jung, Young Joan, Rao Jayaraman, Cook Maureen M, Severt Lawrence and Boyar Karyn. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. : JAMA neurology. 20140707.