Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity.

Offer, Steven M

Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity. [electronic resource] - Cancer research May 2014 - 2545-54 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

1538-7445

10.1158/0008-5472.CAN-13-2482 doi


Amino Acid Sequence
Antimetabolites, Antineoplastic--chemistry
Biotransformation
Dihydrouracil Dehydrogenase (NADP)--biosynthesis
Enzyme Assays
Fluorouracil--chemistry
Gene Frequency
Genetic Association Studies
HEK293 Cells
Humans
Molecular Sequence Data
Mutation, Missense